The E4 begins at the Late Minoan Cemetery of Armenoi, goes up to the peak of Brisinas Mountain (858 m) via a dirt road and then down to Selli.

The view on Rethymno and the Cretan Sea is panoramic from the peak of Vrisinas. The route continues to Mirthios Rethymnou, sidesteps Prases from the south and goes on to Harkia and Kavousi to end up at the Monastery of Arkadi.