The E4 Path enters the Prefecture of Lassithi from the western side of the Dikti Mountains. Leaving the village of Kostanomitsa and the settlement of Tihos, it climbs the old Venetian Trail towards the Plateau of Lassithi.

From the summit you can enjoy the magical scenery of the largest Plateau in Crete below. Ascending the asphalt road towards the village of Kato Metochi, go through it and towards the next village of Aghios Haralambos. E4 now becomes a dirt road. Continuing on you arrive at the village of Psichro, where you can visit the cave in which, according to mythology, the god Zeus was born. Leaving this village, move onwards along the trail towards the villages of Aghios Georgios and Koudoumalia. All of these villages are found within the Plateau of Lassithi and at an elevation of 900 metres. Now your ascent begins, a total of approximately 950 elevation metres. 

Exiting the village of Koudoumalia, you can enjoy the last view of the Plateau, before reaching another much smaller plateau : the Plateau of Limnakaro. Passing by the church of Our Lady, you should take the opportunity of filling your canteens at the nearby farmhouse. On the right slope of the mountain, you can see the shelter "Strovidi" hat belongs to The Climbing Association of the Plateau of Lassithi. The dirt track goes through the small Plateau of Limnakaro and continues uphill to the summit of Seli, which is the highest point of the route at 1800 metres. You will need a total of 3.5 to 4 hours from the village of Koudoumalia to get here. Five minutes before the summit, on your right, you will find the spring of "Avarsami". Here begins the downhill path towards the settlement of Selakano and the magnificent pine forest that is one of the few remaining in the Prefecture.